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KMID : 0370220150590020055
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Yakhak Hoeji
2015 Volume.59 No. 2 p.55 ~ p.58
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Synthesis and NF-κB Inhibitory Activities of N-Substituted-aryl-3-phenylpropanamide Derivatives
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Choi Min-Ho
Kim Young-Soo
Jung Jae-Kyeong
Lee Hee-Soon
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Abstract
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A series of N-substitutedaryl-3-phenylpropanamide derivatives were synthesized and their inhibitory activities on LPS-induced NF-κB transcriptional activity on RAW 264.7 cells were evaluated. Cl substituted derivatives (1e, 1f) have shown more potent activities than parent hit compound KL-1156.
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KEYWORD
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NF-κB, KL-1156, N-substitutedaryl-3-phenylpropanamide derivatives
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